With the success of the first laparoscopic cholecystectomy, laparoscopic techniques have become widely available to surgeons, and to date, the trans-laparoscopic route has been adopted as the standard procedure for many surgeries. Within the field of general surgery, laparoscopy has been applied to a variety of procedures, including liver, pancreas, spleen, and gastrointestinal surgery. However, in the case of retroperitoneal masses, usually because of the large size of the tumor and the involvement of surrounding vessels and other organs at the time of the patient’s visit, transperitoneal surgery may lead to severe abdominal bleeding and even endanger the patient’s life. Therefore, up to now, trans-laparoscopic resection of retroperitoneal masses has been performed in few units and is limited to case reports. The main technical difficulties are effective intraoperative hemostasis and whether the tumor can be completely resected, which requires accurate preoperative evaluation. In addition, effective hemostatic instruments are required. The introduction of laparoscopic ultrasound knife and Ligasure hemostatic instruments has made the difficult surgery possible. Since we started laparoscopic difficult surgery in 2002, we have performed dozens of cases of resection of retroperitoneal masses, including laparoscopic adrenal masses, retroperitoneal neurofibroma, teratoma and other tumors. The success rate of the surgery is over 90%. Patients recover well after surgery, with a recurrence rate of less than 1% at follow-up. Our experience shows that laparoscopic resection of retroperitoneal masses is safe and feasible.