Parkinson’s disease is a common neurological disorder whose incidence increases with age. The main clinical manifestations are tremor, myotonia and slowing of movement. The disease is also characterized by slow progressive development and eventual disability, causing severe physical and thus psychological damage to the patient. Although we cannot stop the progression of the disease itself, with the tremendous progress in drug and surgical treatment over the past 20 years, we do still have many treatments to improve the quality of life of Parkinson’s patients 1. In the early stage, when the tremor, straightness or motor retardation does not affect our quality of life, we can choose non-pharmacological treatment, including exercise, regular life, no smoking and drinking, eating more fruits and coarse fiber food, etc. Some drugs on the market to nourish the brain nerves are not yet effective, and if there are also hypertension, diabetes, hyperlipidemia and other diseases, they should be treated actively. When the disease has progressed to the point where it does affect our quality of life, we need to take medication, which can significantly improve symptoms, thereby improving quality of life and social participation. Medications do not accelerate the progression of Parkinson’s disease. At present, there are many varieties of drugs for Parkinson’s, and they need to be used rationally under the guidance of an experienced neurologist. 2, some misconceptions in drug therapy Drug therapy requires consideration of the patient’s age, the rapidity and severity of the disease, the effectiveness of the drug and side effects and other factors. Generally follow the principle of starting with a small dose and gradually increasing the dose. In order to avoid the appearance of drug side effects, multiple drugs are generally used in combination and do not require complete control of symptoms. Therefore, what we often see in the clinic is that due to the fear of patients and even some doctors to increase the dose of drugs, long-term low-dose medication, many patients are basically in a state of disability, needing companionship and care, with no quality of life to speak of, and gradually lose interest in life, resulting in anxiety and depression and other mental disorders. In recent years, due to the widespread use of brain pacemakers, we no longer need to be afraid of the side effects of drugs. We should use reasonable doses to improve symptoms, enhance the ability to take care of oneself, restore patients’ confidence in life, and live wonderfully. 3. What is a brain pacemaker Parkinson’s disease is an extrapyramidal disease, mainly involving the basal ganglia. The basal ganglia include many nuclei that are closely interconnected, thus precisely controlling the body’s movements. The known mechanism of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra of the brain, resulting in an imbalance of various neurotransmitters in the basal ganglia, which in turn produces the various symptoms of Parkinson’s. A brain pacemaker is the common name for deep brain electrical stimulation, which achieves therapeutic goals by generating electromagnetic fields within certain nuclei in the basal ganglia. It consists of three parts: intracranial stimulation electrodes, a subcutaneous pulse generator in the chest, and an extension wire connecting the first two, similar to a pacemaker, with minimal surgical trauma. The diameter of the stimulation electrodes and the extension wire is 1.3 mm, and the length, width, and thickness of the subcutaneous pulse generator in the chest are 70*61*12 mm, which is smaller if it is rechargeable. After surgery, these devices are located under the skin and do not affect walking, bathing and daily life. 4.When to consider surgery The natural course of Parkinson’s disease is fast and slow, ranging from a few years to decades. In the early and middle stages, the effect of medication is very good, but generally after 6 or 7 years, different degrees of on/off phenomenon, end-of-agent phenomenon, heterokinesia and body dysmorphia will appear. When these symptoms appear, DBS surgery should be considered. When the patient is already bedridden and the trunk and limbs are severely deformed, the surgery is too late and the results are poor. The long-term results of DBS surgery are good, and most patients can moderately reduce the dosage of drugs after surgery, improve the adverse drug reactions, so that patients can get a new life and re-fill their confidence in life.