White blood cells may increase in primary thrombocythemia, but it is not a specific diagnostic indicator, and the disease can be treated with medication chemotherapy and surgery. The cause of primary thrombocythemia is not clear, and it usually presents with symptoms such as thrombosis and splenomegaly. In addition to the typical abnormally high platelet counts, routine blood tests are often accompanied by leukocytosis, and eosinophils and basophils may be elevated, but red blood cell counts are usually normal. The diagnosis of primary thrombocythemia is made by platelet counts and bone marrow biopsies; white blood cells are not diagnostic. Pharmacologic treatment of the disease includes the use of myelosuppressive drugs such as butyl nitrogen mustard dimethylsulfonate, antimetabolites such as hydroxyurea, and antiplatelet agents such as aspirin. These drugs should be used under the guidance of a clinician, and unauthorized use is prohibited; if primary thrombocythemia is suspected, it is recommended to go to the hospital in time for consultation.