The so-called “STD phobia” is a neurological disorder in which patients with STDs or other people have a fear of STDs. According to statistics, 50-80% of people with STDs have this disorder, and about 20% of them have more obvious symptoms. People who suffer from STD phobia are very afraid of STDs and often wonder if they have contracted an STD. Some have no history of sexual contact and no suspicious symptoms, positive signs or laboratory evidence of STDs, but they are still on edge. Some have a history of unclean sex, but after physical examination and laboratory tests, STDs have been ruled out, or they have been cured of STDs, but their suspicions are still not dispelled; some suspect that the doctor’s medical skills are low, and some think that the laboratory tests are inaccurate, so they keep changing doctors and hospitals just in case. The majority of patients have increased selective attention, both to the outside world information about STDs highly concerned, including going to bookstores, browsing websites, collecting newspaper information, etc.; but also to their own organs related to the slightest changes and discomfort highly sensitive, and will take the initiative to “right”, as if self-taught “STD experts “The first thing you need to do is to take a look at the information in the newspaper. Some of them tell their medical history like a treasure, and repeatedly emphasize the details they think are related to STD to remind the doctor’s attention; some of them repeatedly question all-round from multiple angles, and remain half-hearted despite the explanation; some of them are stubborn, and always need a “comprehensive examination”; some of them put the discomfort of other parts of the body hard and STD ” Some of them will be hard and STD”; some of them suspect that their family has been infected with STD all the time (in fact, it is not true), so they are repentant and in pain. These patients are mostly fearful, depressed and even anxious, often reporting dizziness, headache, insomnia, dreaminess, palpitations, poor appetite, tinnitus, etc.. They often feel poor urination, discomfort at the urethra, lower abdominal cramps, and back or waist pain. Some patients also experience impotence, premature ejaculation, decreased libido, menstrual disorders, and fatigue. A few patients also present with manifestations of plant nerve dysfunction at the time of consultation, such as accelerated pulse, cardiac arrhythmia, facial flushing, excessive sweating, and trembling hands. However, the most critical external genital and systemic examinations did not show any positive signs of STDs, and none of the laboratory tests concerning STDs showed any abnormal findings. As the saying goes, “the heart disease must be treated by the heart”. The most important thing for patients like this is psychological treatment. The doctor should explain to the patient the basic knowledge about STD, the explanation should be logical, the conclusion should be clear and unambiguous, the explanation should be in-depth and easy to understand. If necessary, the relevant clinical and laboratory tests can be done again to completely eliminate their doubts. For certain symptoms that the patient feels, appropriate symptomatic treatment can be given; for example, sedatives can be used for insomnia, and drugs for stomach and digestion can be used for loss of appetite. If the above treatment does not work after 3 months or seriously affects work and life within 3 months, then the patient should see a psychiatrist and take relevant medications.