Tumor metastasis has a poor prognosis and its formation involves many pathological mechanisms. Recent studies have shown that tumor cells express specific chemokine receptors, while their metastatic sites highly express the corresponding ligands, which are chemotactic to tumor cells, resulting in the “homing” theory of tumor cell-directed metastasis. This theory suggests that intervening in the interaction between receptors and ligands may be a new approach for anti-tumor metastasis therapy. We hereby review the recent research progress on chemokines and their receptors involved in the directional metastasis of tumors.