How is squamous cervical cancer treated?

  Cervical cancer is the most common gynecologic malignancy, and the main histologic type is squamous cell carcinoma, followed by adenocarcinoma. Squamous cell carcinoma of the uterine cervix is divided into exophytic, endophytic, ulcerative, and cervical canal types, and is histologically highly differentiated, moderately differentiated, and poorly differentiated. The high incidence age is 50 to 55 years old, and in recent years its incidence has a tendency to be younger. With the common application of cervical cytology screening, cervical cancer and precancerous lesions can be detected and treated early, and the incidence and mortality rate of cervical cancer have been significantly reduced.  Appropriate individualized treatment plan is formulated based on clinical stage, patient’s age, fertility requirements, general condition, medical technology level and equipment conditions. The general principle is to adopt a comprehensive treatment plan based on surgery and radiotherapy, supplemented by chemotherapy.  1.Surgical treatment is mainly used for early stage cervical cancer patients. Commonly used surgical procedures include: total hysterectomy; sub extensive total hysterectomy and pelvic lymph node dissection; extensive total hysterectomy and pelvic lymph node dissection; abdominal para-aortic lymphadenectomy or sampling. Younger patients with normal ovaries may be preserved. For young patients requiring preservation of reproductive function, conical hysterectomy or radical hysterectomy is feasible for those belonging to particularly early stage.  2.Radiotherapy Applicable to patients with intermediate to advanced stage; early stage patients whose systemic condition is not suitable for surgery; preoperative radiotherapy for large cervical lesions; adjuvant therapy for high risk factors found in pathological examination after surgical treatment.  Chemotherapy is mainly used for patients with advanced stage or recurrent metastasis. In recent years, surgery combined with preoperative neoadjuvant chemotherapy (intravenous or arterial infusion chemotherapy) is also used to shrink tumor lesions and control subclinical metastasis, as well as to sensitize radiotherapy. Commonly used chemotherapeutic drugs include cisplatin, carboplatin, paclitaxel, bleomycin, isocyclophosphamide, fluorouracil, etc.