The early Framinghan Heart Study showed that the risk of all types of cardiovascular events was 2.3 and 2.47 times greater in men and women with diabetes than in non-diabetic patients, respectively. The concept of “diabetes as an equivocal risk for CHD” was introduced in the 2002 National Cholesterol Education Program Adult Treatment Guidelines III (ATPIII). Like traditional cardiovascular disease risk factors such as smoking, hypertension, and hyperlipidemia, hyperglycemia is also associated with cardiovascular disease. Together, these risk factors lead to impairment of vascular endothelial function, which in turn leads to atherosclerosis and ultimately to cardiovascular and cerebrovascular events. Currently, under the guidance of a large number of evidence-based medicine, antihypertensive, lipid-regulating, and antithrombotic therapy have been increasingly emphasized by cardiovascular physicians, and cardiovascular disease has been more comprehensively intervened, but the problem of cardiovascular disease combined with hyperglycemia has still not been fully appreciated. Numerous evidence-based medical trials have shown that nearly 2/3 of patients with coronary artery disease have hyperglycemia: the 2004 European Heart Survey showed that more than 2/3 of patients with coronary artery disease have hyperglycemia, including 31% with abnormal glucose tolerance and 12% with newly diagnosed diabetes. The NAVIGATOR study, an international multicenter intervention, showed that 2/3 of patients with various cardiovascular diseases had hyperglycemia. 2006 Chinese Heart Survey showed that about 80% of patients with coronary heart disease had hyperglycemia in combination. The Glucose Intolerance in Acute Myocardial Infarction (GAMI) study showed that nearly 2/3 of patients with acute myocardial infarction also had hyperglycemia. At a mean follow-up of 2.8 years, patients with acute myocardial infarction with abnormal glucose tolerance had a significantly higher incidence of composite endpoint events (heart failure, recurrent myocardial infarction, stroke, death, etc.) than those with normal glucose tolerance. Thus, the very high proportion of patients with cardiovascular disease combined with hyperglycemia and the increased risk of cardiovascular disease must be taken into account.