The 13-valent pneumococcal polysaccharide conjugate vaccine is used to prevent 13 pneumococcal serotypes, while the 23-valent pneumococcal polysaccharide vaccine is used to prevent 23 different pneumococcal serotypes. The two vaccines differ in terms of the applicable population, so the decision of whether to do 13-valent or 23-valent after 2 years of age depends on the child’s specific situation.1. 13-valent pneumococcal polysaccharide conjugate vaccine: There are two types of pneumococcal polysaccharide conjugate vaccine commonly used in China, which are imported and domestically produced, of which the imported 13-valent pneumococcal polysaccharide conjugate vaccine is mostly given to infants and children from 6 weeks to 15 months of age, and people after 2 years of age may not receive this vaccine; and The domestic 13-valent pneumococcal polysaccharide conjugate vaccine is intended for infants and children from 6 weeks of age to 5 years of age, and the latest vaccination time is before the 6th birthday. 2. 23-valent pneumococcal polysaccharide vaccine: it covers more serotypes than 13-valent, and is suitable for people above 2 years of age. The 23-valent pneumococcal polysaccharide vaccine is not recommended for infants and children under 2 years of age, and the 13-valent pneumococcal polysaccharide conjugate vaccine can provide a better immunization effect for this population.