Large vessel disease is one of the most dangerous diseases in clinical practice, which seriously threatens people’s health. The Department of Cardiovascular Surgery of Wuhan University People’s Hospital has started the clinical treatment of abdominal aortic aneurysm since the 1970s, and has launched basic research on surgical interventions for large vessel diseases. At present, we are able to carry out all clinical treatment techniques for large vessel diseases, including complex surgeries such as full arch replacement of aorta, Bentall, Wheat’s, David’s, “elephant trunk” surgery, Hybrid hybrid surgery, etc., which have become the advantageous features of our department. In the past ten years, we have completed more than 700 cases of major vascular surgery, with a success rate of 98%. The treatment service has been radiated to Jiangxi, Henan, Hunan and other surrounding provinces and regions. The etiology of large vessel diseases is complex, mainly including congenital arterial structural defects, acquired degenerative lesions, mechanical trauma, autoimmune diseases, infections and other factors. With the development of diagnostic technologies such as vascular ultrasound, multi-row CT and angiography, the diagnosis of large vessel diseases has become easier. Our center is equipped with excellent talents in vascular ultrasound and CT imaging to provide strong and powerful guarantee for the diagnosis of this disease. We are currently working on laboratory serological diagnostic studies of aortic coarctation, with the aim of obtaining serological indicators for epidemiological screening of aortic coarctation. In terms of large vessel treatment, our center has its own advantages and characteristics. In terms of surgical procedures, in 1998, the center was the first in Hubei province to carry out total arch replacement for aortic coarctation under deep cryopreservation, which has become the most competitive specialty of our department. At the same time, we were the first to perform cerebral protection with a modified bilateral paracavalvular cerebral perfusion technique under direct vision through the cephalobrachial trunk and left common carotid artery cannulation, which significantly reduced postoperative cerebral complications and greatly improved the surgical level and treatment effect of complex cardiovascular malformations and macrovascular diseases in China. In terms of interventional treatment, in the past decade, endovascular stenting has been widely used for aneurysms of the abdominal and thoracic descending aorta and Stanford B aortic coarctation, and has achieved good short and medium-term results, greatly reducing the risk of surgery and the morbidity and mortality rate. As for the integration of multidisciplinary techniques, we have gradually combined endoluminal techniques with surgical procedures in the treatment of aortic arch lesions, because it is often difficult to obtain sufficient anchorage areas for endoluminal stent implantation due to the three important branches of the cephalic trunk, the left common carotid artery and the left subclavian artery, and complete endoluminal implantation of branch-type stents is unlikely to be widely performed in the short term. This is known as “hybrid technique”. Compared with traditional surgery, which has high trauma, mortality and complication rates, hybrid surgery does not require extracorporeal circulation, is less traumatic, has rapid postoperative recovery, and has achieved good therapeutic results, and may become the next standard solution for the surgical treatment of arch diseases. Our department started to carry out this new technique in 2009, and the technique has matured in 2010, and has been applied to more than 100 patients so far, with surgical complications controlled within 10% and good prognosis in the near future.