High alkaline phosphatase in liver function tests may be related to physiological factors, medications, or may be caused by bone disease or hepatobiliary disease. 1. Physiological factors: Elevated alkaline phosphatase can occur during childhood, adolescence, pregnancy, or when eating foods with high fat content, and is often mildly elevated. Such physiological causes are normal and generally do not require special treatment. 2. Drugs: High alkaline phosphatase may occur when patients are treated with long-term antibiotics or barbiturates. The phenomenon of high alkaline phosphatase caused by such drugs generally does not require special treatment and can return to normal after discontinuation of the drug; 3, skeletal diseases: because alkaline phosphatase is more active in bone tissue, high alkaline phosphatase may occur in patients with skeletal diseases, such as rickets, chondromalacia, fracture healing period, osteoporosis, malignant tumors of bone, malignant tumor bone metastases, etc.. Such cases require active treatment of the primary disease to relieve the symptoms. If osteoporosis should be actively supplemented with calcium, vitamin D, while applying calcitonin, zoledronic acid to inhibit osteoclasts, so as to control the phenomenon of high alkaline phosphatase; 4, liver and biliary diseases: such as biliary obstruction, cirrhosis, etc., because the liver cells have more alkaline phosphatase, so if the liver problems, alkaline phosphatase will be high. Treatment should be promptly to the hospital to clarify the cause of symptomatic treatment, such as biliary obstruction can be applied surgically to lift the obstruction, cirrhosis can be taken to anti-viral root cause of the disease. In addition, some patients with hyperparathyroidism and capillary biliary hepatitis may also have high alkaline phosphatase as a result of liver function tests. Therefore, the causes of high alkaline phosphatase are complex, so it is recommended to consult a doctor promptly and cooperate with him/her to improve other related tests after the examination is clear.