Sciatica can be caused by lumbar disc herniation, pyriformis syndrome, etc. It can be treated with oral non-steroidal anti-inflammatory drugs and nutritive nerve medication according to the cause. 1. Lumbar disc herniation: When lumbar disc herniation compresses part or all of lumbar 4 and 5 nerves and sacral 1, 2 and 3 nerve roots, it can cause sciatica symptoms, such as lumbar or lower limb pain and limb sensory impairment. For lumbar disc herniation, non-steroidal anti-inflammatory and analgesic drugs such as bisacodyl, celecoxib, etc., or combined with nutritive drugs such as methylcobalamin can be used to alleviate the symptoms of nerve root pain. 2. Piriformis syndrome: the main symptom of piriformis syndrome is sciatica, and the treatment is mainly based on oral non-steroidal drugs, commonly used drugs such as celecoxib, indomethacin, diclofenac, meloxicam, etc. If the pain symptoms are significant, it can be treated with oral non-steroidal anti-inflammatory and analgesic drugs such as diclofenac. For those with significant pain symptoms, oral tramadol hydrochloride extended-release tablets can be taken. Sciatica is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, under the guidance of the doctor to use drugs.