The C2 stage of atrophic gastritis does not have a direct impact on life expectancy, so the exact number of years of survival needs to be determined based on a combination of physical condition and the presence of other subsequent diseases. Early treatment helps the health of the gastrointestinal tract. Atrophic gastritis C2 means that the patient’s condition has developed atrophic lesions of the gastric mucosa, which may spread to the corners of the stomach. Atrophic gastritis is a common benign lesion of the gastrointestinal tract, which may lead to the emergence of mild dyspepsia, impairment of gastrointestinal function and other symptoms, but does not affect the survival life. If intestinalization and intraepithelial neoplasia occur and are not treated in time, they may become malignant and can affect life expectancy. Since most of the episodes of atrophic gastritis are related to Helicobacter pylori infection, the diagnosis and treatment can start with comprehensive drug treatment of Helicobacter pylori, which can eradicate Helicobacter pylori infection by choosing amoxicillin, clarithromycin, omeprazole, and bismuth pectin for comprehensive treatment. After the symptoms of atrophic gastritis, it is recommended to carry out gastrointestinal protection treatment as soon as possible, which can improve the health of the gastrointestinal tract through dietary modification, and to carry out gastroscopy on a regular basis.