Congenital heart disease is not a hereditary disease, but there is a genetic predisposition. Children of mothers or fathers with congenital heart disease are much more likely to develop congenital heart disease than the normal population, while acquired heart disease is generally not related to genetic factors and will not be passed on to children. 1. In general, congenital heart disease has a genetic predisposition, such as hypertrophic cardiomyopathy, Marfontein syndrome, Brugada syndrome, and long QT syndrome. 2. Congenital heart disease is also related to environmental factors during pregnancy, such as early pregnancy infection with viruses, rubella, influenza, etc., taking too much sedative drugs, oxytetracycline, tetracycline and other antimicrobial drugs, glucose is not well controlled, X-ray exposure. 3. Many hereditary diseases, such as trisomy 21, trisomy 18, and short-arm deletion of chromosome 5, are associated with congenital heart disease. 4. Acquired heart disease is generally related to dietary habits, bacterial and viral infections, etc. It does not lead to changes in one’s own genes, and is generally not related to genetic factors and will not be passed on to the child. It is recommended to go to the hospital for further counseling on whether or not heart disease is hereditary and whether or not it will be passed on to the child.