Propofol is a strong, short-acting intravenous general anesthetic with rapid onset, short duration of action and rapid recovery. It is mainly used for the induction and maintenance of surgical anesthesia and for outpatient minor surgeries such as gastroscopy, enteroscopy, and abortion. In addition to these anesthetic effects, small doses of propofol have hypnotic and sedative effects. The application of propofol in any situation should be with respiratory support. Only anesthesiologists are qualified to use propofol. So, why was Michael obsessed with an intravenous general anesthetic, propofol? Allegedly, Michael had been taking Valium-type hypnotic and sedative drugs for a long time due to insomnia, and his family doctor gave him propofol due to its lack of efficacy. Due to the excessive dose and the lack of respiratory monitoring, not to mention the lack of conditions for respiratory support, he eventually died of respiratory depression. In addition to the anesthetic effect, hypnotic, sedative effect, there is an important role of propofol, is the nerve, mental effects, it can lead to euphoria, euphoria, sexual fantasy, floating, beautiful dreams, etc., this effect and another anesthetic ketamine (i.e. K powder) that is similar and different, K powder can lead to euphoria, exhilaration, can also lead to uncomfortable, nightmares, etc.. Some patients are in pursuit of the psychoactive effects of propofol, leading to propofol abuse, psychological dependence or even addiction. Eventually it is impossible to extricate oneself! In order to counteract the psychoactive effects of anesthetic drugs such as propofol or chlorambucil, we generally have to apply another intravenous general anesthesia such as midazolam at the same time during clinical anesthesia, which, in addition to its own powerful general anesthetic effects, can also inhibit the neuropsychoactive effects of propofol, reducing euphoria, fantasy, beauty dreams, etc., and can produce amnesia. Michael, a generation of musical kings, died from propofol, it is a pity!!!!