Novel coronavirus pathogenesis

  Novel coronaviruses exist for human-to-human transmission and can be transmitted in multiple ways, including respiratory, contact, and fecal-oral. The novel coronavirus itself carries an S-protein, which recognizes and interacts with the ACE2 protein on human respiratory epithelial cells, thus opening the door for the novel coronavirus to invade the human body.  The novel coronavirus enters the human body through ACE2 and suppresses ACE2, causing some metabolic types of diseases such as hypertension, diabetes, and coronary heart disease. The novel coronavirus enters the body through ACE2 and not only starts its unbridled replication and multiplication, but also suppresses ACE2, thus causing morbidity in the body.