Fever in the middle of the night in infants is mostly considered to be related to physiological factors, as well as disease factors, such as colds, pneumonia, acute enteritis, etc. Low fever can be cooled by warm water baths and other methods, while acetaminophen and ibuprofen suspension can be applied to reduce fever in severe cases. Also need to drink more warm water to promote metabolism and relieve discomfort. If it is difficult to reduce the fever to 38.5℃ or more, or if the symptoms cannot be relieved for a long time, it is recommended to go to the hospital in time. I. Physiological factors: When babies are teething, they will stimulate slight inflammation of the gums, which may lead to a fever in the middle of the night, but it will subside on its own after a few days. Second, disease factors: 1, cold: due to cold, pathogens invasion and other reasons leading to pediatric colds, children can appear in the middle of the night fever, nasal congestion, runny nose, sneezing, coughing and other symptoms. Parents need to give their babies water several times and pay attention to timely wiping sweat to avoid getting cold. At the same time, monitor the body temperature, once the rise is obvious, need to promptly go to the hospital for medical attention; 2. Pneumonia: the onset of the disease is more acute, with pre-cold symptoms, such as fever in the middle of the night, cough, sneezing, 1-2 days after the cough aggravated, appear episodes of dyspnea, wheezing and other symptoms. After going to the hospital, usually need antibiotic treatment to control the infection, such as mycoplasma pneumonia can choose macrolides, such as erythromycin, roxithromycin, etc.; 3, acute enteritis: infants in the pathogenic bacteria infect the intestinal tract, can lead to acute enteritis, can appear symptoms of fever, generally can be accompanied by diarrhea, crying, etc., need to use sensitive antibiotic treatment, with rehydration treatment; 4, other: hand, foot and mouth disease, tonsillitis 4, other: hand, foot and mouth disease, tonsillitis, central nervous system infection and many other diseases can lead to fever in the middle of the night infants, should promptly seek medical examination, clear cause after treatment.