Diabetes may affect the relationship between husband and wife. Diabetes will bring pathological changes to the patient’s body, such as physical weakness, panic, drinking, eating, urinating and many other symptoms, if the blood sugar is poorly controlled for a long time, impotence, premature ejaculation and other symptoms may occur. Diabetic patients affected by physical discomfort may experience depression, anxiety, irritability and other bad emotions. The original harmonious relationship between husband and wife will slowly change under the long-term influence of diabetic patients’ bad mood. Diabetes requires long-term treatment and medication, and the patient’s treatment requires certain costs, which may even affect the diabetic’s original job and income, and the family’s economy changes as a result. In order to minimize the impact of diabetes on the relationship between husband and wife, it is recommended that diabetic patients go to the hospital in a timely manner to control their blood sugar at the desired level.