You can stay up late after vaccination, but it is not recommended. Most of the body’s metabolism takes place at night, and staying up late can jeopardize your health and affect your body’s rhythmicity. Staying up late after the vaccination will affect the absorption and metabolism of the vaccine in the body and will not maximize the effect of the vaccine. Also, after vaccination, the body may experience severe or mild antibody reactions, such as dizziness, headache, weakness and sleepiness. If you stay up late after vaccination, the body’s resistance will decrease, which may aggravate the adverse reaction and even lead to symptoms such as fever and drowsiness, as well as cover up the cause, i.e. it is difficult to determine whether the relevant discomfort is caused by staying up late or by the vaccine, which is not conducive to dealing with the cause after clarification, so it is not recommended to stay up late after vaccination. In addition, staying up late often can lead to a decrease in the body’s resistance, and various bacteria and viruses can take advantage of the situation, resulting in upper respiratory tract infections, fever, and gastrointestinal discomfort. For women, staying up late can also lead to changes in hormone levels, causing irregular menstruation, and may even lead to a higher chance of breast cancer. Staying up late can also increase the intensity of the work of the heart, prone to arrhythmia, which in the long run may lead to heart disease. Therefore, it is recommended to maintain a stable body resistance before getting vaccinated. After the vaccination, you should avoid local water, and also ensure sufficient rest, a light diet, or appropriate exercise.