Normally, anti-inflammatory drugs are not recommended within 3 days after vaccination, however, if a more serious bacterial infection does exist and the need for anti-inflammatory drugs exists, anti-inflammatory drugs can be taken under the guidance of a doctor. Anti-inflammatory drugs are not necessary if they are intended to improve symptoms such as localized redness, swelling and pain after the vaccination. If you happen to have a bacterial infection after the vaccination, you can take anti-inflammatory drugs as prescribed by your doctor if you have a more serious bacterial infection as determined by blood tests and CRP after visiting the hospital. Although taking medication at this time may increase the adverse effects of the vaccine, if anti-inflammatory medication is not applied, the condition may be delayed and worsened, so on balance, anti-inflammatory medication can be used as prescribed for the purpose of controlling the condition. If you are not sure about the presence of bacterial infection, you should not apply anti-inflammatory drugs at will in order to avoid the risk of double adverse reactions. On the one hand, because vaccination is prone to vaccine-related adverse reactions such as fever, diarrhea, rash, etc., if anti-inflammatory drugs are taken it is possible to increase the incidence of adverse reactions and also the chance of allergy, because both vaccines and anti-inflammatory drugs may cause allergic reactions. On the other hand, anti-inflammatory drugs must be used only when there is an indication for bacterial infection, and the application of anti-inflammatory drugs without certainty of bacterial infection can easily lead to bacterial resistance and will not be effective in the treatment of the disease.