Adrenocorticotropic hormone is a peptide hormone secreted by the pituitary gland. High adrenocorticotropic hormone may be caused by tumors, or by diseases such as Addison’s disease and congenital adrenocortical hyperplasia. 1. Tumors that appear in the pituitary gland or other parts of the body that secrete too much adrenocorticotropic hormone can cause hypercortisolism, also called Cushing’s syndrome. There can be a full moon face, buffalo back, even fat pads on the clavicle, centripetal obesity, purple lines on the skin and other manifestations of increased secretion of high cortisol. 2. Addison’s disease: Addison’s disease is also known as primary hypoadrenocorticism, patients may have low blood pressure, generalized weakness, loss of appetite, nausea and vomiting, skin and mucous membrane pigmentation and other symptoms. Eddie’s disease may also present with elevated adrenocorticotropic hormone. 3. Congenital adrenocortical hyperplasia: Congenital adrenocortical hyperplasia is an autosomal recessive disorder caused by congenital defects in enzymes required in the synthesis of glucocorticoids. The pituitary gland is stimulated by negative feedback, resulting in increased production of glucocorticoids. If the phenomenon of elevated adrenocorticotropic hormone occurs, it is recommended to improve the relevant examination, identify the cause and then treat the symptoms.