For acute urticaria with a clear cause, avoiding re-exposure to triggering factors and giving antihistamines can lead to a cure. Chronic urticaria is usually difficult to identify the cause of the disease, and can be repeated. Clinical commonly used antihistamines to treat urticaria, mainly including cetirizine, loratadine, fexofenadine, ibastine, imipramine, olopatadine and so on. When taken, the drugs can reduce the release of histamine from the skin and can help relieve itching. If acute urticaria develops rapidly and there is a tendency to respiratory distress, subcutaneous injection of epinephrine followed by systemic glucocorticoid therapy is required. Chronic urticaria, the cause of which is often difficult to define, requires long-term oral antihistamines, combined with hydroxychloroquine and tretinoin if necessary. Recurrence of urticaria is relatively common, mainly due to re-exposure to allergens. If urticaria often recur, if necessary, to the hospital dermatology department, or desensitization treatment, can reduce the recurrence of the disease, the specific use of drugs need to follow the doctor’s instructions.