Cholinergic urticaria, can be treated with antihistamines, anticholinergic, anti-anxiety depression, biologics drugs, glucocorticoid drugs, botulinum toxin, immunosuppressants and other drugs. 1. Antihistamine: excessive release of histamine from the skin may lead to itching, antihistamines can be given, such as fexofenadine and ketotifen, which have antihistamine and anti-allergic effects, and are helpful in relieving itching. 2. Anticholinergic: Anticholinergic drugs such as scopolamine butylbromide and methylphenidate bromide can be given in combination with doctor’s opinion, which can block the release of parasympathetic vinylcholine and histamine in smooth muscle. 3. Anti-anxiety, depression: cholinergic urticaria in patients with anxiety and depression, give doxepin and other drugs when necessary, have sedative antihistamine effect, also anticholinergic activity. 4. Biological inhibitors: biological agents class of drugs are common omalizumab, can block immunoglobulin-mediated allergic reactions, can reduce the recurrence of the disease. 5. Glucocorticoids: Glucocorticoids, such as methylprednisolone sodium succinate, can be given for obvious allergic symptoms, which can help to relieve the symptoms. 6. Botulinum toxin: Botulinum toxin injections can also be given to relieve symptoms. 7. Immunosuppressants: Immunosuppressant medications, such as cyclosporine, can also be given to treat cholinergic urticaria, which can control symptoms and also reduce flare-ups. It is recommended that patients with cholinergic urticaria should go to the dermatology department of the hospital and be given appropriate medication under the guidance of the doctor.