The symptoms of mastocytosis are mainly characterized by periodic pain in the breast. Initially, the pain is diffuse and swollen, and the tenderness is obvious in the upper and middle part of the breast, and the pain increases before menstruation every month and decreases or disappears after menstruation. In severe cases, the pain is persistent before and after menstruation. Sometimes the pain radiates to the armpit, back of the shoulder, upper limbs, etc. Patients often report a lump in the breast, but only a thickened breast gland is palpable during clinical examination. A very small number of adolescents with simple lobular hyperplasia can heal themselves in about 2 years, while most patients need treatment. After suffering from mastopathy, a considerable number of patients do not pay enough attention to it, delaying consultation or just seeking relief from breast pain symptoms, without realizing the potential danger of mastopathy – that is, a small number of mastopathies that do not heal for a long time can develop The potential risks of mastocytosis are not realized – that is, a small number of mastocytic hyperplasia can develop benign tumors or malignant lesions if left untreated for a long time. Patients with mastoproliferative disease who have atypical clinical manifestations or no obvious premenstrual breast pain, but only breast lumps, especially unilateral single, hard lumps, should be distinguished from mammary fibroadenoma and breast cancer. 1) Mastocytosis and fibroadenoma: Both can be seen as a single or multiple breast lump with a firm texture. Most breast lumps in mastoproliferative disease are bilateral and multiple, varying in size, nodular, lumpy or granular, generally soft, or hard and firm, occasionally unilateral and solitary, but mostly accompanied by premenstrual breast swelling and pain when touched, and the size and nature of breast lumps may change periodically with menstruation. Most breast lumps in mammary fibroadenoma are unilateral, round or ovoid, with clear borders, high mobility, and generally firm texture, but there are also multiple cases, but there is usually no breast swelling and pain, or only mild menstrual breast discomfort and no tenderness. In addition, on mammograms, breast fibroadenomas often appear as round or ovoid shadows of uniform density and their characteristic ring-shaped transparent halo, which can be an important basis for differential diagnosis. 2) Mastoproliferative disease and breast cancer: Both of them can be seen as breast lumps. However, breast lumps in mastocytosis are generally soft or moderately hard in texture, mostly bilateral, variable in size, and may be nodular, lumpy or granular, movable, without adhesion to skin and surrounding tissues. Breast lumps are usually hard, some are as hard as stone, most of them are unilateral, round, oval or irregular in shape, and can grow to a large size, with poor mobility and easy adhesion to the skin and surrounding tissues. In addition, on the mammogram of breast, breast cancer often appears as lump shadow, tiny calcified dots, abnormal vascular shadow and burr, which can also help in the diagnosis. Mass needle aspiration of breast cancer can find heterogeneous cells and the final diagnosis needs to be based on histopathological findings.