New Year’s Eve, it is friends and family to get together, drink, show a good mood of the time! At this time, drinking has become a relaxation, the best way to contact feelings, however, there is a class of people must be done “drop of alcohol does not touch”, otherwise, it may take your life! Not long ago, they encountered such a patient, Li Mou, 40 years old, engaged in the communications industry, suffering from chronic prostatitis for many years, the recent recurrence of the disease, and then came to the clinic, the Department of the “cephalosporin” medication given to the patient to take on a regular basis, while informing the patient can not drink, the patient went home to adhere to the medication, but has long been the doctor’s words thrown to the Not two days later, the patient’s family suddenly sent the patient to the emergency room of our hospital, the patient’s performance at that time for facial flushing, dizziness, headache, nausea, vomiting, blood pressure was measured only 87/64mmHg, after a careful examination of the patient after inquiring about the patient in the morning to take “antibiotics”, and at noon with a colleague, the patient took “cephalosporin” drugs, and at the same time told not to drink alcohol. After careful examination and inquiry, it was learned that the patient took “antibiotics” in the morning, and just “sipped two glasses” with his colleagues at noon. Speaking of which, the doctors of the Emergency Department knew that there was a “disulfiram reaction”, and the patient was cured and discharged from the hospital by the Emergency Department’s active treatment. What is disulfiram reaction: disulfiram-like reaction, also known as withdrawal sulfur-like reaction, is due to the application of drugs (cephalosporins) after drinking drinks containing alcohol (or contact with alcohol) resulting in the body of the “acetaldehyde accumulation” of the toxic reaction. After alcohol enters the body, it is first oxidized to “acetaldehyde” by “ethanol dehydrogenase” in liver cells; acetaldehyde is oxidized to “acetic acid and acetaldehyde dehydrogenase” by “acetaldehyde dehydrogenase” in mitochondria of liver cells. Acetaldehyde is oxidized in the mitochondria of liver cells by the enzyme “acetaldehyde dehydrogenase” to “acetic acid and glyoxalase A”, and acetic acid is further metabolized to carbon dioxide and water and excreted. Due to the presence of “methylthiotetrazole side chain” in some chemical structures, the activity of acetaldehyde dehydrogenase in the mitochondria of hepatocytes is inhibited, so that acetaldehyde cannot be oxidized and metabolized further after it is produced, leading to the accumulation of acetaldehyde in the body and the occurrence of the bisulphuric reaction. What are the symptoms of disulfiram reaction: drinking alcohol (or exposure to alcohol) during the use of medication, patients may manifest chest tightness, shortness of breath, laryngeal edema, cyanosis of lips and mouth, dyspnea, increased heart rate, drop in blood pressure, weakness of the limbs, facial flushing, excessive sweating, insomnia, headache, nausea, vomiting, bleary-eyed, drowsiness, hallucinations, trance, and even the occurrence of anaphylactic shock, blood pressure dropped to 60 ~ 70/30 ~ 40mmHg, with the accompanying symptoms of disulfiram. 40 mmHg with loss of consciousness. In addition, the severity of disulfiram-like reaction is directly proportional to the dose of drugs and the amount of alcohol consumed. Drinking liquor is more severe than drinking beer or alcoholic beverages, and drinking alcohol while taking the drug is more severe than drinking alcohol after stopping the drug. Which drugs drinking during taking can appear disulfiram reaction: 1, cause disulfiram-like reaction of the drugs are cephalosporins and imidazole derivatives. Cephalosporins cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefradine (Pioneer VI), cefmetazole, cefminox, raxephosporin, cefmetaxime, cefamandole, cefadroxil (Pioneer Ⅳ), cefaclor and so on, which cefoperazone to cefsulfuric acid reaction caused by the report of the most, the most sensitive, such as the patient in the use of the heart of wine after eating chocolate, If a patient eats alcohol-centered chocolate, takes patchouli, or even treats the skin with alcohol only, a disulfiram-like reaction may occur. Cefotaxime, ceftazidime, cefsulodine, cefazoxime, cefixime, because it does not contain methylthio-tetrazolium group, during the application of alcohol will not cause disulfiram-like reaction. 2, in addition to metronidazole (metronidazole can inhibit the metabolism of alcohol, drinking alcohol after taking the drug may appear abdominal pain, vomiting, headache and other symptoms), tinidazole, ketoconazole, furazolidone, chloramphenicol, toluene sulfobutyl urea, glibenclamide, phenelzine, and so on, can cause disulfiram-like reaction. What should I do if I have a disulfiram reaction? Once a disulfiram reaction occurs, the drug and ethanol-containing products should be discontinued immediately. Mild cases can be relieved on their own, while more serious cases need to be sent to the nearest hospital for active treatment to avoid shock or even death!