The combination of pharmacotherapy and psychotherapy remains the best treatment option in the clinical management of severe OCD. For now, pharmacological treatment is clinically based on 5-hydroxytryptamine reuptake inhibitors as the drug of choice, and the recommended drugs of choice are sertraline, fluvoxamine, fluoxetine and paroxetine. During the course of treatment, full doses and courses of treatment are applied for at least 10-12 weeks to assess the effect of the drugs. In addition, during the treatment process, it is still important to insist on systematic psychotherapy. Psychotherapy is currently clinically recommended to use cognitive-behavioral therapy and Morita therapy. The main gist of cognitive behavioral therapy is to challenge the compulsive thoughts that cause irrational cognition, identify intrusive thoughts, cognitive reframing strategies and other techniques to achieve the treatment goal. In addition, the main therapeutic principle of Morita therapy is to go with the flow and do what is right. When obsessive-compulsive symptoms exist and cannot be overcome by oneself, one has to be open to accept them, put things in one’s own experience by accepting the appearance of various symptoms, and then while the symptoms exist, pursue the natural state to experience the quality of life to resolve the obsessive-compulsive symptoms. These are the two basic approaches to OCD treatment.