Severe cleanliness, possibly OCD. It will affect normal study, work, life and social intercourse. Its treatment methods include: 1, psychotherapy: including Morita therapy, cognitive therapy, behavioral therapy, hypnotherapy, etc.; 2, medication: including sertraline, fluoxetine, fluvoxamine, etc. Most patients have good results with medication; 3, surgery: if medication is ineffective and seriously affects the patient’s life, work and study, surgery can be considered. At present, minimally invasive surgery, including brain stereotactic surgery and deep brain electrical stimulation, is mostly used in clinical practice.