It is not possible to generalize whether a booster vaccination can cause hives. If it causes an allergic reaction to the vaccine, it may lead to urticaria, while other causes should be excluded. 1. The general situation that does not cause urticaria: If the basic immunization does not induce urticaria, the body has never had an allergic reaction, and there is no allergy to the vaccine components, the booster shot will not cause urticaria in general. 2. Possibility of triggering urticaria: If you are allergic, this booster shot may trigger urticaria. Of course, it is also necessary to exclude the possibility of allergy to other substances, or mechanical urticaria. If the booster vaccination triggers hives or other uncomfortable symptoms, you should take appropriate treatment measures as prescribed by your doctor.