The main pathogenesis of gastric ulcer is the invasive effect of gastric acid and pepsin, and the loss of balance between mucosal defense function, gastric acid and pepsin produce self-digestion of gastric mucosa, and pepsin is only active in the case of gastric acid, so inhibiting gastric acid can also inhibit pepsin. I. The main causes of pathogenesis: 1, Hp infection, i.e. Helicobacter pylori infection is the main cause, eradication of Hp can accelerate ulcer healing and reduce recurrence; 2, aspirin and other non-steroidal drugs, glucocorticoids, chemotherapy drugs, etc.; 3, duodenal gastric reflux, stress, smoking, mental factors, irregular eating, etc. Second, clinical standardized treatment plan: 1, inhibition of gastric acid secretion: including famotidine, ranitidine and other H2 receptor blockers, pantoprazole, rabeprazole and other proton pump inhibitors (PPI), which have a strong acid-suppressive effect and can make the stomach free of gastric acid and enhance the bactericidal effect of Hp antimicrobial agents. 2, eradication of Hp infection: amoxicillin, clarithromycin, etc. 3, gastric mucosal protective agents: including bismuth such as bismuth in pectin and aluminum thioglycollate gel, weak alkaline antacids. The use time of 1 of them is 4-6 weeks, and the use time of 2-3 is 1-2 weeks, then review the gastroscopy until the ulcer is healed.