What is pain? The World Health Organization and the International Association for the Study of Pain define pain as “pain is an unpleasant sensory and emotional experience caused by tissue damage or potential tissue damage”. She is the fifth vital sign after blood pressure, temperature, respiration, and pulse, and the elimination of pain is a fundamental right of the patient. As one of the most successful surgeries in the 20th century, the purpose of joint replacement surgery is to eliminate pain and restore the function of the joint, which is the most effective treatment for end-stage joint diseases. It has become the common goal of our joint surgeons and anesthesiologists, and we have achieved good results through comprehensive application in recent years. First, pre-surgical analgesia. The purpose of these drugs is to reduce the patient’s hypersensitivity to pain caused by joint disease, to increase the patient’s pain threshold and to reduce the patient’s reaction to pain. And after the corresponding initial anesthesia has taken effect, some invasive operations such as catheterization are performed to further reduce the patient’s discomfort. Furthermore, the intraoperative minimally invasive operation improves the quality of surgery and shortens the operation time. The size of the surgical incision is not an indicator of minimally invasive operation. Minimally invasive operation means that the concept of minimally invasive operation is applied throughout the entire operation, protecting the corresponding muscles, ligaments, blood vessels, and nerves around the joint, operating in the gap that exists naturally in the human body structure as much as possible, applying relevant instruments in the joint capsule, applying surgical tools skillfully and accurately, ensuring quality and completing the joint replacement in as short a time as possible. The surgical incision can be closed with the application of some local anesthetic drugs for nerve block, so that the patient does not experience painful irritation quickly after the end of general anesthesia. The next step is the application of a self-administered pain pump. By placing some intravenous or nerve block pain pumps, the patient can control the application of drugs by himself, and when I feel pain, I can press the control device and give myself some drugs. In terms of drug selection, an optimal combination of multiple drugs can be carried out to achieve pain relief and prevent some complications such as vomiting and addiction. Finally, proper functional exercise after surgery, active recovery, and further cooperation with medication when needed. After joint replacement, patients should actively cooperate with doctors for proper functional exercise, which will eliminate limb swelling and reduce thrombosis. If patients still have pain during the functional recovery period, they can moderately reduce the exercise amplitude and cooperate with some medications to achieve “pain-free” joint replacement and less painful functional exercise. In conclusion, multi-modality analgesia and multi-session analgesia will bring more benefits to patients undergoing joint replacement surgery.