Patient: Diagnosed with osteosarcoma of the left distal femur in October 01, chemotherapy + HIFU treatment (high intensity focused ultersound). In October 2008, Dr. Guo Wei performed left knee replacement, GMRS. After functional exercise, the joint function has recovered well. Main problem: The temperature of the outer side of the joint has always been slightly higher, more obvious in the evening, and slightly better in the morning, but still higher than the temperature of the inner side of the joint or the joint of the other leg. The joints are not red or swollen, but only for basic daily walking. If the joints are swollen after too much walking, the swelling goes down the next day without any action. Blood count, sedimentation, C-reactive protein, X-ray uniformly normal. Antibiotics + Cilostro + topical Fitalin + ice packs are effective, but when stopped, the temperature of the lateral aspect of the joint remains slightly elevated. Does this indicate aseptic inflammation? Does it need to be treated? Thong Soon: I am glad to meet you. Although I have not directly treated your disease, I should have a better understanding of your situation. First of all, we have studied and discussed the situation you described. For tumor joints, it should be said that the normal body will react to it, but not all reactions will develop into rejection of the prosthesis. Secondly, in your case, due to your small size and limited soft tissue coverage around the prosthesis, the body is weak in absorbing the small amount of fluid and resisting the reaction to the prosthesis. I think this situation does not need special treatment, pay attention to observation, regular review, maintain moderate activity can be, I hope my answer you can be satisfied.