In our daily life, we often hear people say: “In recent days, I have insomnia again, I can’t sleep at night, and I have no energy to work during the day, it’s too hard, if anyone can let me sleep, let me do as much work as possible. This is the real state of mind of an insomniac. Yes, people who do not have insomnia experience can not appreciate the pain caused by insomnia, especially in the dead of night, see others lying in bed soon to fall asleep, even they are eager to have their own snoring, the pain is insomniacs lying in bed, like ants on a hot pot, in bed constantly turning over, sweating, anxious mood, etc., then people will think of using sleeping pills to improve their sleep. This is when people think of using sleeping pills to improve their sleep. Since the introduction of sleeping pills, people have different views on sleeping pills, some people think that sleeping pills do not do anything; some people think that sleeping pills are addictive; some people think that sleeping pills can improve sleep; some people love and hate sleeping pills, without it really can not. How much do you know about sleeping pills? The first generation of sleeping pills, including barbiturates, chloral hydrate and tribromine, have the pharmacological effect of selectively inhibiting the brainstem reticular upstream agonist system. Since the brainstem reticular upstream agonist system has an important function in maintaining our wakefulness, its inhibition reduces the excitability of the cerebral cortex, which leads to the feeling of drowsiness. The disadvantage is that it has a low therapeutic index and is easily tolerated and dependent; a moderate dose can suppress breathing. The second generation of sleeping pills are benzodiazepines, commonly known as “Valium”. Its efficacy and safety, so far more than 2000 kinds of synthetic. They are divided into three categories: short-acting, medium-acting and long-acting, of which the half-life of short-acting benzodiazepines is less than 10 hours, with rapid and short-lived effects. It is easy to have dependence and can easily produce rebound insomnia after withdrawal. Midazolam has a half-life of 1.5-2.5 hours, and triazolam has a half-life of 2-3 hours. Medium-acting benzodiazepines have a half-life of mostly 10-20 hours, with residual reactions at higher doses. Commonly used drugs include hydroxyzolium, chlorohydroxynil, estradiol and alprazolam. Long-acting benzodiazepines have a half-life of 20-50 hours, of which flunitrazepam is the shortest and fluoroketamine is the longest, reaching 40-100 hours. Its slow action and long duration of efficacy make it prone to accumulation and residual reactions, as well as respiratory depression. The third generation of sleeping drugs is a new type of sedative-hypnotic drugs, whose characteristics basically do not change the normal physiological sleep structure and are not easy to produce dependence and tolerance. They include zolpidem, zopiclone and zaleplon. Among them, zolpidem has a positive effect on difficulty in falling asleep, easy to wake up and dreamy; zopiclone is less likely to cause hangover; zaleplon is used for the early treatment of insomnia, improving the quality of sleep in the first half of the night, without rebound insomnia.