The main clinical manifestations of all types of pediatric leukemia are basically similar, and the onset of the disease can be acute or slow. Anemia Progressive anemia is one of the prominent symptoms of pediatric acute leukemia, anemia often manifests as pale mucous membranes, skin and weakness, and even shortness of breath and dyspnea after activity, anemia occurs mainly due to infiltration of normal bone marrow by leukemia cells, but the degree of bone marrow involvement is not completely consistent with anemia. Hemorrhage is seen in most children with acute leukemia, with varying degrees of severity, and the bleeding sites are mostly in the mucous membranes of the skin, mouth and nasal cavity, often with purple skin seizures and even large subcutaneous petechiae. Gastrointestinal bleeding, urinary tract bleeding is often seen in the later stages of the disease, while intracranial bleeding is common at the end stage and is one of the main causes of death. The enlarged lymph nodes of the liver and spleen are more common in the neck, followed by the occipital region and behind the ear, and the enlarged lymph nodes of the whole body are also more common, usually with mild enlargement, hard texture and no painful adhesions, but when the mediastinal lymph nodes are obviously enlarged, they can cause symptoms of compression and respiratory difficulties. Hepatosplenomegaly is also a common symptom in childhood leukemia, especially in acute gonorrhea, and hepatosplenomegaly is generally soft in texture and without pressure. Other system involvement manifests in childhood leukemia, due to the infiltration of leukemia cells into tissues and bleeding, the clinical symptoms of various system involvement can be manifested. （In recent years, with the progress of leukemia treatment, the survival period of leukemia patients has been prolonged, and many chemotherapeutic drugs cannot pass the brain barrier, so the leukemia cells remaining in the central system are able to multiply, and central nervous system leukemia occurs. The cerebrospinal fluid pressure and protein are increased, and the white blood cell count is increased, mainly by leukemic cells. (b) Testicular infiltration, in addition to the central extensor system is a common site of involvement, the testes are also one of the organs often infiltrated, clinical conscious symptoms less unilateral or bilateral testicular enlargement as the main symptom, a few patients have a feeling of swelling and pain, slightly hard local. （The kidney is also one of the most frequently involved organs, and clinical changes in urine, hematuria, proteinuria, etc. are often seen. (iv) Pulmonary infiltrates, clinical symptoms are mostly lung infections. The first symptoms of childhood leukemia are not obvious and should not be ignored by parents, and need to be seen in a regular children’s hospital, parents can contact me by phone if they have any other questions