The side effects of applied botulinum toxin are generally not very serious, mainly because the skin has a better barrier effect and can block some of the drugs from entering the body, so the effect of applied botulinum toxin is weaker and the side effects are relatively less. However, people who have thin skin stratum corneum, use too much Botox, or use too high a concentration of Botox, have a higher chance of side effects and the side effects are relatively more severe. Botulinum toxin can be applied to remove facial wrinkles by blocking the excitatory transmission of the neuromuscular junction to achieve muscle relaxation, and can also cause disuse atrophy of the muscles to improve facial contours, such as slimming the face. The effect of botulinum toxin in relaxing muscles will cause some patients to have a stiffness of facial muscles such as weakness of eyelid lifting, eyebrow drooping, dull expression, and weakness of mouth opening after application. These symptoms can generally recover slowly as botulinum toxin is discontinued and the effect of the drug disappears, but if the condition is serious and damage is caused to the facial nerves, recovery may be slower or may even be impossible. In addition, if there is a botulinum toxin allergy, the use of applied botulinum toxin may also result in localized skin redness, rash, swelling, pain and other symptoms, and some patients with serious conditions may also experience fever or even shock. If you have an allergic reaction, you need to go to the hospital immediately to avoid serious consequences. People who want to remove wrinkles can choose laser and electric wave to remove wrinkles, in addition to using Botox. Daily life should also pay attention to skin cleaning and maintenance, reduce the burden on the skin, avoid staying up late, moderate exercise, which helps to reduce the generation of wrinkles.