Osteoarthritis: Osteoarthritis develops slowly and can last for several years, mostly in middle-aged and older people over 40 years old, 10% of whom have significant symptoms. Symptoms commonly include joint pain, fever, swelling, and limited movement. Joint stiffness is more pronounced in the morning, but lasts for a short time, less than 20 minutes. Osteoarthritis usually affects only certain joints, such as the hands, hips, knees and spine, but can affect the wrists, elbows or ankles if trauma occurs. Rheumatoid arthritis: Usually develops between the ages of 25 and 50 and can occur suddenly, starting in the small joints bilaterally, causing redness, heat, swelling, and morning stiffness of the joints that can last for several hours. Rheumatoid arthritis often involves multiple joints, including the finger, wrist, elbow and shoulder joints, and often leads to fatigue and weight loss. Osteoarthritis and rheumatoid arthritis are both chronic joint diseases systemic diseases that can involve joints of all sizes, but they are still fundamentally different and must be differentiated. 1, rheumatoid arthritis is more frequent in middle-aged women, while osteoarthritis is more frequent after the age of 50. The basic lesion of rheumatoid arthritis is synovitis, while osteoarthritis is mainly degenerative changes in joint cartilage and osteophytes. 3, rheumatoid arthritis involves the proximal interphalangeal joints, while osteoarthritis mainly involves the knee, hip, spine and distal phalangeal joints. 4, rheumatoid arthritis is persistent, symmetrical and progressive arthritis, without treatment rarely remission; osteoarthritis is asymmetrical arthritis, its long course, high disability rate. 5, rheumatoid arthritis has rheumatoid nodules, osteoarthritis common Herbden’s nodes, Bouchard’s nodes. 6, rheumatoid arthritis patients with morning stiffness up to more than 1 hour, osteoarthritis patients with morning stiffness lasts less than half an hour. 7, rheumatoid arthritis patients rheumatoid factor positive rate of 75%, osteoarthritis patients rheumatoid factor is negative.