Mr. Z is 35 years old, more than a decade, he has been a piece of mind, he married twice, but a healthy baby has been a “big problem”. “His ex-wife had two pregnancies, but they were both miscarriages.” Mr. Z said he thought the miscarriages were his wife’s problem, but he couldn’t find any abnormalities. Because of the lack of children, the couple often complained about each other, and finally had to go their separate ways. After that, Mr. Z got married again, but he did not expect that his second wife also had two babies, and they were all miscarried naturally because of embryonic sterilizations. Mr. Z took his wife to the hospital to check, but can not find the results, until the doctor suggested that he went to the hospital to do chromosome examination, the results of the examination surprised him, the original, leading to his wife’s miscarriage of the “main culprit” is actually their own. It turned out that his chromosome 9 and chromosome 16 were in a translocation. Chromosomal balance of patients can be male, can also be female. It is understood that this carrier in the population of about 0.2%, that is, 250 normal couples have a carrier. Before that, due to the lack of scientific knowledge, some people thought that “miscarriage is all a woman’s problem”, and they all put the blame on the female partner, and some women could not hold their heads up because of this. Literature reports that 10-15% of married couples suffer from infertility, of which the male factor accounts for 50%; and chromosomal abnormalities caused by male infertility and accounted for 18-20% of male infertility. Chromosomal abnormalities account for a high percentage of male infertility. The rate of chromosomal abnormality in couples with multiple miscarriages is about 3.2%-4.9%, which is significantly higher than that of the normal population (0.5%). The main manifestations are embryonic arrest in early pregnancy and repeated miscarriage. About 60% of aborted embryos within 12 weeks of gestation had chromosomal abnormalities, and the rate of chromosomal abnormalities decreased significantly to about 7% after 24 weeks of gestation, suggesting that spontaneous abortion due to chromosomal abnormalities is a way of natural selection in human evolution. With the development of gene probes and recombination technology, the relationship between chromosomes and infertility will be gradually elucidated. The following 9 kinds of people need chromosome examination: 1. Obvious developmental abnormalities, malformations and mental retardation. 2.Two or more miscarriages and infertile couples. 3. Those with abnormal development of gonads and external genital organs. 4, Patients with azoospermia or severe oligospermia. Couples who have already given birth to children with chromosomal abnormalities. 6. Women with primary amenorrhea. 7, long-term exposure to X-ray, ionizing radiation, toxic chemicals, exposure to rays during pregnancy (it should be noted that computers also have rays), antitumor drugs and other personnel. 8.Patients with malignant blood diseases. 9. Pregnant women over 35 years of age.