A clear obstetric history of abnormalities that can lead to intrauterine distress, and severe intrauterine distress (fetal heart rate <100 beats for more than 5 minutes; and/or amniotic fluid degree III contamination, or a history of significant asphyxia during delivery); 2. Severe asphyxia at birth, defined as an Apgar score of ≤ 3 points at 1 minute, which is still ≤ 5 points at 5 minutes, and/or an umbilical artery blood gas pH of ≤ 7.00 at birth; 3. Neurological symptoms shortly after birth that persist for more than 24 hours, such as changes in consciousness (hyperventilation, lethargy, coma), changes in muscle tone (elevated or increased), or changes in muscle strength (elevated or increased). pH ≤ 7.00 3. Neurological symptoms appearing shortly after birth and persisting for more than 24 hours, such as altered consciousness (hyperexcitability, lethargy, coma), altered muscle tone (increased or decreased), abnormal primitive reflexes (sucking and cuddling reflexes diminished or absent), convulsions, brainstem signs (altered respiratory rhythms, pupil alterations, blunted or absent light response), and increased fontanel tone; 4. Electrolyte disorders, non-asphyxial causes, or other causes of asphyxia, are excluded. Exclude electrolyte disorders, intracranial hemorrhage not due to asphyxia, and convulsions due to birth injury, as well as intrauterine infections, hereditary metabolic disorders, and brain damage due to other congenital disorders.