In the United States, behavioral risk factors and obesity are more common among those with low SES. In wealthy populations, unhealthy lifestyles may account for up to 70% of colorectal cancer incidence. Although epidemiological and biological studies suggest that unhealthy lifestyles may contribute to colorectal cancer, why these lifestyles affect so many people of low SES remains unclear. To determine how behavioral risk factors and obesity affect low socioeconomic status populations, data from the National Institutes of Health AARP Diet and Health Study were examined. They surveyed patients from six U.S. states and two large cities from 1995-1996 and followed them until 2006. The participants’ health habits were derived from questionnaires and the health habits of people at low socioeconomic levels were derived from self-reported education and census data. This study showed that more than one-third of patients with invasive adenocarcinoma of the colon and rectum were at high risk associated with low socioeconomic status, which could explain the differences in morbidity among patients exposed to different behavioral risk factors, especially unhealthy diet. Effective public health strategies to improve the nutritional and physical status of the U.S. population and to stem the tide of obesity, especially among those with less education and those living in environmentally depressed communities,” added, “These efforts could help ensure a steady decline in the incidence of colorectal cancer, which has increased rapidly since the post-1975 decade has increased rapidly.