Lifestyle plays an important role in the risk of colorectal cancer. Factors such as overweight, low physical activity, smoking, alcohol consumption, and diet; each of these factors is associated with the risk of colorectal cancer development. Between January 1992 and December 2000, 347,237 adult men and women from 10 European countries were recruited to provide information on diet and lifestyle habits. An average of 12 years was observed, and eventually 3759 people developed colorectal cancer (2369 colon and 1390 rectal). The results found that 36% of rectal cancer cases in men and 20% of colon cancer cases in women could be attributed to non-adherence to a healthy lifestyle. A combination of healthy weight, non-smoking, and healthy diet may reduce the risk of colorectal cancer. Lifestyle changes, especially healthy weight, non-smoking, and a healthy diet, can reduce colorectal cancer. Lifestyle changes are essentially cost-free and have no risks or side effects. Doing so will reduce mortality from not only colorectal cancer, but also from many other chronic diseases and cancers. P.S. Lifestyle changes to reduce colorectal cancer: exercise, healthy diet, smoking cessation, controlled or moderate alcohol consumption, and weight control. Healthy diet: consume more fruits, vegetables, dietary fiber, fish, nuts, garlic and yogurt, and consume less red or processed meats.