In the previous treatment concept for cancer pain, pain relief on demand was more advocated, which means that patients take painkillers when they are in pain and the pain will be relieved with it, and then use painkillers again when they feel pain again. This type of medication is characterized by the fact that because it takes time for the medication to take effect, the patient always has to go through a period of pain, which in turn leads to an overall pain relief that is not very effective and is also prone to drug resistance. In 1982, the global promotion of the three-step treatment program, which advocates the timely administration of medication, that is, according to the principle of drug metabolism (pharmacokinetic principles) to medication, painkillers in the body has a natural metabolism of the process, with the extension of time, the concentration of the drug will gradually decline. According to the slow-release process of drug preparations and the principle of drug metabolism in the human body, the medication on time, you can maintain the balance of effective blood concentration in the body. For example, the oral slow-release preparation of morphine is usually administered once every 12 hours; fentanyl transdermal patch is administered once every 72 hours, and this time interval is based on the results of pharmacokinetic studies. Therefore, it is important to follow the doctor’s instructions and use the medication on time throughout the treatment process. Are strong opioid analgesics such as dulcolax and morphine addictive? After the Opium War, Chinese people have always been “scared of drugs”, making cancer patients reluctant to use strong opioid analgesics when they have pain. In fact, drugs and narcotics are two different concepts. Drugs are strong opioid substances used by drug addicts for the pursuit of spiritual enjoyment, the use of which is usually by nasal inhalation or intravenous injection, and drug addicts often do not use morphine for the pursuit of fast-acting drugs, but change to heroin and methamphetamine, which are faster and stronger in effect, and at the same time are more prone to psychological dependence; while painkillers are generally used for treating the discomfort of the body and are not for the pursuit of spiritual enjoyment, and are not for the pursuit of spiritual enjoyment, and are not for the pursuit of spiritual enjoyment. not for the pursuit of mental enjoyment, and the use of extended-release formulations of pain medications is inherently effective in minimizing risks such as physical tolerance and addiction. In addition, due to the relatively high drug side effects of Dulcolax, the State has explicitly banned the use of this drug in 1996, and replaced it with morphine, which is more effective and has fewer side effects. What if I become drug resistant to pain medication after a period of time? Drug tolerance is a common occurrence in drug therapy, especially with opioid pain medications. However, it is possible to delay the onset of tolerance as long as possible through skillful use of the medication. The body has an opioid countermeasure called MNDA receptor activation. The use of opioids, the human body’s MNDA receptor is also activated at the same time, the degree and speed of its activation depends on the mode of administration, the injection or immediate-release oral morphine tablets will induce the rapid activation of the receptor, so that the effect of pain medication will soon be reduced; and slow-release preparations of pain medication can be maintained for a long time, the effective blood concentration, the degree and speed of activation of the MNDA receptor will also be reduced, the therapeutic effect will be The therapeutic effect will be maintained for a longer period of time. Therefore, it is important to grasp this medication technique and try to maintain the effective time of the medication. In addition, many patients are already in the terminal stage of cancer, and some of them may have passed away before the emergence of drug resistance. So you can only try to make the pain as effective as possible during this time to ensure a better quality of life. Do these pain medications have any other side effects? Will they speed up the patient’s disease progression or death? Morphine has a variety of effects on the body. For cancer pain, pain relief is the main effect, and then everything else can be considered a side effect. Common side effects include nausea, vomiting, and poor appetite, but patients will recover on their own after a week without special intervention. The most difficult and common clinical problem is constipation. After morphine and other opioid analgesics enter the intestines, the intestines are full of opioid receptors, which are easy to combine with morphine, slowing down intestinal peristalsis, and making the bowel movement even slower, so that constipation is formed after a long period of time when the stools tend to dry out. Especially patients with advanced cancer, due to malignant tumors will consume physical energy, resulting in stools more difficult to discharge on their own. However, these side effects are generally not too serious for the human body, and if they affect normal life, clinicians will adjust the medication accordingly. It is certain that morphine analgesics used to control cancer pain will not lead to immune suppression and accelerated death. On the contrary, due to effective analgesia, it can enhance the quality and duration of survival of patients and improve their prognosis, which is a beneficial treatment for patients with severe pain.