Analgesic treatment is sufficient if it results in partial pain relief. Pain relief is the key to improving the patient’s quality of life; the minimum requirement for pain management is to achieve pain-free sleep; a true improvement in the patient’s quality of life should include: pain-free sleep, pain-free rest, and pain-free activities. Long-term use of narcotic painkillers can be “addictive”. “Addiction” is characterized by a persistent, relentless craving for opioids, not for pain relief, but for “euphoria. Pain management efforts have led to a significant increase in the use of opioid pain medications, yet the number of opioid abusers has declined, and the medical use of opioid pain medications has not increased the risk of opioid abuse. Taking large doses of opioids can be toxic. There is no capped dose of opioids, and the appropriate dose for pain relief is the one that provides adequate analgesia without intolerable side effects for the duration of action. Opioid painkillers should not be used as a last resort. Prolonged lack of effective pain relief can interfere with sleep, appetite, and lower the patient’s resistance, thus giving the disease a chance to develop further. Pain can mostly be well controlled by oral medication. The higher the morphine dose, the more severe the disease. Pain is a “subjective” sensation with significant variability; the dose of analgesic required for the same intensity of pain may not be the same; some patients require a high dose of morphine to achieve pain control; the size of the morphine dose does not reflect the severity of the disease, let alone an estimate of the length of survival. The next dose of morphine can be withheld when there is no pain. Depends on the circumstances. If the patient is completely unconscious, refusal may be unreasonable. In this case, continued persuasion to receive morphine is necessary. On the other hand, if the blurring of consciousness is associated with paranoia (threatened or persecuted feelings), even gentle persuasion can worsen the condition. If the patient is suspected of having delusions of persecution, it is not advisable to reintroduce morphine; instead, help should first be sought by telephone from his physician or the home bed nurse. If it is due to confusion rather than an intentional refusal to take morphine, there should be reason to reduce the amount of morphine. The patient may be right: morphine causes him unacceptable drowsiness or nausea; or severe adverse effects such as intractable constipation, so that perhaps it is a case of trading one affliction for another, i.e., the adverse effects of taking morphine are even more painful than the pain. In response, the dosage of morphine needs to be reduced as appropriate. Clearly, there is a need to explore the reasons for this, or to understand the possible reasons behind the refusal to take morphine. Specialist advice and help should also be sought.