Urticaria has the potential to cause hand edema. Urticaria is due to a variety of reasons lead to the dilatation of small blood vessels under the skin mucosa and vascular permeability increased, and a limited edema, usually accompanied by intense itching, also known as the clinic, the skin scratch disease will be presented as a positive. Localized edema caused by urticaria is characterized by a rapid appearance as well as a rapid disappearance, and the wheals can appear within minutes or disappear completely within minutes to hours without leaving any trace. Urticaria can appear in all parts of the body, so it is also possible to appear in the hands. In addition to itchy bumps, severe cases may involve the digestive and respiratory systems, resulting in nausea, vomiting, abdominal pain, difficulty breathing, and even choking. For edema caused by urticaria, standardized treatment should be carried out under the guidance of a doctor.