The incidence of pancreatic endocrine tumors is about (1-4)/100,000 people, accounting for only 1%-2% of pancreatic tumors, and can occur at any age, with a male to female ratio of about 13:9, with a trend of gradual increase in recent years. Symptoms of disease Pancreatic neuroendocrine tumors can be divided into “functional” and “non-functional” tumors according to whether they cause clinical symptoms or not. The former is classified as insulinoma, glucagonoma, glucagonoma, vasoactive intestinal polypeptide secreting tumor, growth inhibitory tumor, etc. The “non-functional” tumors may not produce no neuroendocrine substances, but just do not cause specific clinical symptoms. The common clinical manifestations of endocrine tumors of the pancreas are shown in Table 1.