Nasopharyngeal cancer is a relatively common malignant tumor of the nasopharynx, and the treatment is mainly based on radiotherapy treatment, supplemented by chemotherapy or other treatments. Radiotherapy not only treats the lesion site, but also damages the surrounding normal tissues, so it will produce some radiotherapy sequelae. The common radiotherapy sequelae include: dry mouth, dental caries, difficulty in opening mouth, hearing loss, deafness, dizziness, change of taste sensation, fibrosclerosis of the neck, etc. Such sequelae are not the most serious after the end of radiotherapy, but become more and more serious in several years with the prolongation of time. The main reason for dry mouth and tooth decay is the irradiation damage to parotid gland during radiotherapy, which makes the amount of saliva secreted by parotid gland drop sharply, thus patients often feel dry mouth; the lysozyme in saliva decreases sharply, and some patients have severe caries and tooth destruction after radiotherapy. The main means of prevention include paying attention to oral hygiene, rinsing the mouth after meals, brushing teeth with fluoride toothpaste, and repairing or extracting bad teeth in the mouth before radiotherapy. Difficulty in opening the mouth occurs mainly due to the high dose of radiation to the temporomandibular joint. In some patients, mouth opening is severely restricted, which affects eating and speaking. Necessary mouth opening exercises during and after radiotherapy can reduce its incidence, such as holding a cork in the mouth and mouth opening and closing exercises. The occurrence of hearing loss, deafness, and dizziness is associated with high doses of irradiation received to the middle and inner ear. There are no effective preventive measures except for reducing the dose of radiotherapy. The altered sense of taste is the result of the destruction of taste buds due to radiotherapy, which is usually recovered two to four months after the end of radiotherapy, but some cannot be recovered. The principle of care is to adopt a soft diet with high protein, high calories and high vitamins, and avoid stimulating and excessively cold and hot foods. Fibrosclerosis of the neck is the fibrosis of the neck muscles and skin caused by radiotherapy. Active neck rotation exercises may reduce its severity. Most of the sequelae after radiotherapy for nasopharyngeal cancer can be gradually relieved by patients’ own exercise. Therefore, for patients treated with radiotherapy for nasopharyngeal cancer, they must actively exercise to minimize the after-effects of the sequelae so as not to lead to more serious symptoms.