Urticaria is not recommended to be injected with New Crown vaccine during acute exacerbation. Urticaria is a relatively common skin disease, the patient mainly manifested as localized skin with wind-bubble-like changes, accompanied by itching of the skin, can be given antihistamines such as loratadine under the guidance of the doctor to treat. During this period, it is not recommended to receive the new crown vaccine, so as not to cause further aggravation of the disease. New crown virus is highly contagious and spreads mainly through the respiratory tract and close contact. Vaccination is a relatively simple, efficient and safe way to prevent infection. Adverse reactions such as low-grade fever, dizziness, fatigue and rash may occur after vaccination, which are usually mild and may resolve on their own within a short period of time. Vaccination with the New Crown vaccine in the presence of urticaria is easily confused with adverse reactions to the vaccine, and is therefore not recommended during a flare-up. Patients with urticaria should consult the medical staff before vaccination to see if they can receive the vaccine.