Clinical symptoms of adrenal gland disease: 1. Weakness: It is the main symptom in the early stage, and the degree of weakness is proportional to the severity of the disease. In severe cases, it may reach the point of inability to turn over or reach for objects. Severe muscle spasms, especially in the legs, are also seen. These muscle lesions may be related to imbalance of sodium and potassium balance at the neuromuscular end plate. Weight loss: Gastrointestinal disorders such as loss of appetite, nausea and vomiting, bloating and diarrhea due to cortisol deficiency, reduced fat stores and muscle wasting can lead to weight loss, and progressive and significant weight loss indicates possible adrenocortical crisis. 3, hyperpigmentation: Because the feedback inhibition of pituitary ACTH, melanocyte stimulating hormone (MSH) and lipotropic hormone (LPH) is weakened after the lack of cortisol, the secretion of these hormones is increased, and ACTH and LPH contain α and β-MSH structure respectively, so the skin and mucous membrane pigmentation, friction, palm lines, areola, scars and other places are especially obvious. Hyperpigmentation is one of the main bases for differentiating primary and secondary hyperalgesia, and sudden deepening of pigmentation may indicate deterioration of the disease. 4. Cardiovascular symptoms: Due to the weakened antihypertensive response to catecholamines, blood pressure decreases, with upright hypotension being the most common. x-ray shows a reduced heart shadow, ECG shows low voltage, and prolonged P-R and Q-T intervals. Patients often have dizziness, blurred vision, and upright syncope. 5. Hypoglycemia: Patients have increased sensitivity to endogenous and exogenous insulin and are prone to hypoglycemia under conditions such as starvation, gastrointestinal dysfunction and infection. 6.Neurological symptoms: such as apathy, drowsiness and even mental disorders. 7.Decreased resistance to various stresses such as infection and trauma, which may easily induce adrenal crisis. Extremely sensitive to anesthetics, tranquilizers and hypoglycemic drugs, a small amount can cause coma. 8, sexual dysfunction: both male and female patients can have hypogonadism, female adrenal gland source androgens to maintain sexual hair and libido, so female axillary hair, pubic hair thinning or loss, menstrual disorders or amenorrhea, hypogonadism. If the cause is autoimmune, there may also be premature failure of ovarian and testicular function.