Bee venom therapy is a natural treatment (Naturopathpy) that has been used in some countries around the world for more than 1200 years and has been used clinically in China, Korea, and the Soviet Union. The bee needle is a self-defense organ of the bee. When the bee senses that its life is threatened by other organisms, it performs a stinging action, and while stinging, the bee injects a liquid from the needle, which contains chemical components that produce a local or systemic reaction for the organism stung by the needle, and we refer to the liquid produced by the bee sting as bee needle fluid. Bee sting healing experience combined with the medical art of acupuncture and moxibustion developed the bee needle therapy, which is a combination of needle, medicine and moxibustion. ”Needle”: refers to the bee’s tail sting like a needle, which can stimulate the meridians and skin of the human body to unblock the meridians and regulate the qi and blood; “medicine”: refers to the bee needle in the bee needle liquid into the human body, playing a series of pharmacological effects of the bee needle liquid; “moxibustion “: is the bee needle sting, local congestion and redness, skin temperature increases, seems to have a warm moxibustion effect, can play the role of warming the meridians and channels, to support the positive and eliminate evil. The bee needle following the meridian scattering method is light stimulation, the meridian point direct sting method is medium stimulation, and the live bee sting method is strong stimulation, depending on the individual response to discriminate treatment. The theoretical basis of the meridian theory of bee acupuncture has improved the efficacy of the original bee sting method. The use of live bee needles injects volatile components of bee needle liquid into the body, which cannot be replaced by bee needle liquid medicine. The bee needle is the bee’s self-defense organ. When the bee senses a threat to its life from another creature, it performs a stinging action, and while stinging, the bee injects a fluid from the needle that contains chemical components that produce a local or systemic reaction for the creature stung by the needle, and we call the fluid produced by the bee sting bee needle fluid.