Recently, some patients with Parkinson’s disease have inquired whether they can receive further treatment with a brain pacemaker DBS after unilateral disfigurement surgery and what the results are after the surgery. We would like to give you a brief answer here. The possibility of surgery is mainly related to the site of destruction and the scope of destruction, which needs to be judged by the nuclear magnetic scanning film of the brain after the destruction surgery. A series of preoperative evaluations are needed to determine the efficacy of the surgery. Regarding only the possibility of receiving brain pacemaker surgery after destruction of GPi nuclei, from the follow-up long-term results of DBS treatment with brain pacemakers in post-destructive surgery Parkinson’s patients under my management and treatment, patients after destruction of GPi can choose to receive bilateral brain pacemaker treatment. Because the main therapeutic nucleus in the current brain pacemaker therapy for patients with Parkinson’s disease is the thalamus primordialis, which is more predominant for the neurological network for the treatment of Parkinson’s disease in which the thalamus primordialis is the relay nucleus, and the GPi is one of the output nuclei in this network. Some patients who undergo GPi destruction and choose bilateral pacemaker therapy in the years following surgery because of recurrent symptoms on the destroyed side or worsening of symptoms in the contralateral limb experience significant improvement in symptoms on both sides after surgery, but the improvement in symptoms on the destroyed side is worse than that on the undestroyed side. In the case of patients who have previously undergone disfiguring surgery for Parkinson’s and wish to continue treatment with DBS, a more rigorous preoperative evaluation will be performed. After all, the high price of DBS equipment is a significant expense for most of our patients. Therefore, it is important to give a clear prognosis before surgery, thus giving the patient and family a choice of whether or not to undergo DBS.