HPV plus CIN grade 1 varies individually depending on each person’s autoimmunity. There is a possibility of self-healing during follow-up observation.CIN grade 1 refers to mild cervical intraepithelial neoplasia.About 65% of patients can return to normal on their own, about 20% of patients usually maintain a stable, non-mutating infection, and only about 15% of patients with CIN grade 1 may develop further infections.CIN is usually accompanied by HPV infection, which refers to the infection of the cervical human papillomavirus.HPV plus CIN1 usually has three outcomes: self-reversal and return to normal, persistent infection with elevated lesion levels, and development of cervical cancer.1. Self-reversal and return to normal: most of the CIN1 clinically resolves on its own in 6 months to a year, and does not require special treatment, but requires regular follow-up and observation, which can be self-healing; 2. Persistent infection with elevated lesion levels: some of the patients who are infected with HPV plus HPV are persistently infected, and some of them may develop further infections. Positive will have a part of the people continue to be infected, because HPV positive can not turn negative by itself, there may be continued infection leading to intermediate or advanced lesions, need to carry out physical and drug treatment, regular hospital check whether the infection of high-risk HPV or whether there is a level of elevation of the situation, through active treatment can be controlled; 3, the development of cervical cancer: if the infection of the HPV is a high-risk type, the cervical epithelial cells due to the role of various factors, cell deterioration occurs. If the HPV infection is high risk type, the epithelial cells of the cervix will deteriorate due to various factors and turn into tumor cells, in which case surgical treatment is required. HPV plus CIN1 can be cured by most people, it is recommended to go to the hospital for regular checkups, and at the same time, maintain good living and dietary habits and a good state of mind, so that you can reduce the chances of HPV high-risk infections.