Diagnosis and treatment of acute pancreatitis

  Pancreatitis is a common surgical emergency because of its rapid onset and dangerous condition in some severe cases. Acute pancreatitis can be divided into biliary, alcoholic, metabolic (hyperlipidemia, hypercalcemia due to hyperparathyroidism, pancreatic duct stones due to various reasons), drug, genetic (abnormal biliopancreatic flow, pancreatic splitting, etc.) and idiopathic according to the cause, but the most common are biliary and alcoholic; edematous pancreatitis and severe pancreatitis according to the severity of the disease; acute pancreatitis, acute recurrent pancreatitis, acute attack of chronic pancreatitis, etc. according to the characteristics of the attack. In addition, there are three types of pancreatitis: acute pancreatitis, acute recurrent pancreatitis, acute attack of chronic pancreatitis, etc.  There are three key points to confirm the diagnosis of acute pancreatitis: 1. typical symptoms, such as persistent epigastric and left upper abdominal pain, the nature of severe pain, knife-like pain, colic, etc.; 2. typical imaging manifestations: such as ultrasound, CT suggestive of pancreatic enlargement, unclear boundaries, peripancreatic exudate, etc.; 3. typical blood amylase and/or lipase changes: blood amylase and/or lipase more than 3 times the normal value.  Acute pancreatitis can be diagnosed if 2 of the above 3 items are met.  The treatment principles of acute pancreatitis are as follows: 1. fasting and water, gastrointestinal decompression, reducing the stimulation of food and gastrointestinal fluid to the exocrine part of the pancreas, reducing the secretion of pancreatic fluid, the so-called “pancreatic rest”; 2. maintaining nutrition and water and electrolyte balance, ensuring the basic physiological needs of the patient, correcting the accumulated losses and continuing losses, especially in the acute phase. In particular, in the acute stage, it is necessary to correct hyperglycemia, hypokalemia and hypocalcemia, and patients with recovered gastrointestinal motility can consider enteral nutrition via jejunal nutrition tube; 3, induce diarrhea to promote defecation, because acute pancreatitis is mostly accompanied by intestinal paralysis or even paralytic intestinal obstruction, a large amount of intestinal contents can not effectively enter the colorectum and then expelled from the body, and a large amount of gas grows in the intestinal cavity under the action of gas-producing bacteria, resulting in increased abdominal pain and abdominal distension. It also promotes the migration of bacteria and endotoxin, which makes pancreatitis become more severe and eventually results in abdominal compartment syndrome (ACS) and multiple organ dysfunction syndrome (MODS). Our hospital generally injects compound Dachaihu Tang from the gastric tube, which is clinically proven to be more effective than western drug preparations such as lactulose, magnesium sulfate and mannitol, and patients resume intestinal peristalsis significantly earlier; 4. Inhibit gastric acid and pancreatic enzyme secretion: such as PPI and growth inhibitors, etc. Although the efficacy is currently considered uncertain, it is still more helpful to improve patients’ symptoms.