Acute pancreatitis is an inflammatory reaction in which pancreatic enzymes are activated in the pancreas due to multiple etiologies causing self-digestion, edema, hemorrhage and even necrosis of the pancreatic tissue. It is characterized by acute epigastric pain, nausea, vomiting, fever and increased blood pancreatic enzymes. The extent of the lesion varies, the milder ones are mainly pancreatic edema, which is clinically common and often self-limiting, with a good prognosis, also known as mild acute pancreatitis. Acute pancreatitis due to different degrees of lesions, the patient’s clinical manifestations are also very different: 1, abdominal pain is the main symptom of the disease: often sudden onset after a full meal and alcohol, abdominal pain is severe, mostly located in the left upper abdomen, radiating to the left shoulder and left lumbar back. In biliary origin, abdominal pain starts in the right upper abdomen and gradually shifts to the left side. When the lesion involves the whole pancreas, the pain range is wider and radiates to the waist and back in a band. 2, abdominal distension and abdominal pain at the same time: it is the result of intestinal paralysis produced by stimulation of the abdominal nerve plexus, which is reflexive in the early stage and caused by inflammatory stimulation of the retroperitoneum after secondary infection. The more severe the retroperitoneal inflammation, the more pronounced the abdominal distension. Abdominal distension can be aggravated in case of fluid accumulation in the abdominal cavity. Patients defecation and exhaustion stop. 3, nausea, vomiting: the symptoms can appear early, often accompanied by abdominal pain. Vomiting is violent and frequent. 4, signs of peritonitis: in acute edematous pancreatitis, the pressure pain is mostly limited to the upper abdomen, often without significant muscle tension. Acute hemorrhagic necrotizing pancreatitis pressure pain is obvious, and there is muscle tension and rebound pain, which is more extensive or extended to the whole abdomen. Mobile turbid sounds are mostly positive. Bowel sounds are diminished or absent. 5, other: milder acute edematous pancreatitis may not be feverish or mildly febrile. Combined biliary tract infection is often accompanied by chills and high fever. In the case of pancreatic necrosis with infection, persistent high fever is one of the main symptoms. If the stone is embedded or the head of the pancreas is enlarged and compresses the common bile duct, gangrene may appear. Patients with necrotizing pancreatitis may have a rapid pulse, decreased blood pressure, or even shock.